Vivitrol is a prescription medication used in the treatment of opioid and alcohol dependence. Administered as an intramuscular injection, it delivers an extended-release form of naltrexone that helps reduce cravings and block the effects of certain substances.
This article examines the duration of the medication’s effects, its mechanism of action, and what to expect during treatment.
What Is Vivitrol and How Does It Work?
This extended-release injectable suspension contains an opioid antagonist called naltrexone. Unlike substances that stimulate receptors in the brain, it binds to them without producing euphoria. This action blocks the effects of opioids and prevents the “high” if a relapse occurs. After the injection, the medication is released gradually into the bloodstream, providing a steady effect for weeks.
Due to its unique qualities, treatment with Vivitrol is a vital option for opioid and alcohol addiction. The medication is also paired with counseling, peer support, and behavioral therapies, offering a more holistic approach to recovery.
How Long Does a Vivitrol Shot Last?
A single injection generally remains effective for about 28 to 30 days. The therapeutic benefits can extend between 25 and 50 days. Because it is an extended-release injection, it maintains consistent levels of naltrexone in the body throughout the dosing period.
To maintain effectiveness, patients must follow a regular monthly schedule. Missing a dose may reduce the ability to block the effects of opioids or control alcohol cravings. For this reason, healthcare providers encourage patients to stay on track with appointments and not delay the next injection.
Why Timing Matters in Vivitrol Treatment
After the last dose, naltrexone levels decline, and the protective effect against substances diminishes. This gap can increase the risk of relapse or overdose. For this reason, healthcare providers emphasize the importance of adhering to scheduled injections and remaining committed to a comprehensive treatment program.
Before starting this addiction treatment, individuals must wait at least 7 to 14 days after their last opioid use to avoid sudden withdrawal symptoms. Beginning too soon can trigger severe withdrawal. Once started, keeping injections consistent helps people in recovery maintain stability and avoid cravings.

Vivitrol as Part of Comprehensive Addiction Treatment
This treatment offers significant benefits but works best as part of a comprehensive plan. This may include counseling, behavioral therapies, and peer support. Combining medication-assisted treatment with behavioral health services improves outcomes for people with substance use disorders.
The injectable option is also valued by individuals who prefer a non-addictive medication. Unlike some other treatments, it does not activate brain receptors. Instead, it blocks the effects of opioids and reduces cravings, strengthening long-term recovery.
Possible Side Effects and Considerations
Common issues include nausea, headaches, and fatigue. Some patients may experience severe injection site reactions that require medical attention. However, it is generally considered a safe and effective medication when administered under the supervision of a healthcare provider. Because it is an injectable treatment, it must be given into the gluteal muscle as an intramuscular injection.
Other risks include negative side effects if someone relapses while using this medication. Since tolerance decreases during treatment, a person could face a higher risk of overdose if they return to use. This is why it is essential to remain in close contact with a treatment provider throughout the process.
Final Thoughts from Raise the Bottom
Vivitrol lasts about 28 to 30 days, with its protective effects sometimes extending up to 50 days. The medication works by blocking opioid receptors, reducing alcohol cravings, and supporting stability during recovery. Staying consistent with scheduled injections and working closely with a healthcare provider is essential for maintaining these benefits.
At Raise the Bottom, we recognize the importance of accessible and effective addiction treatment. Our opioid addiction treatment center in Idaho supports people in recovery by offering evidence-based care, including options like Vivitrol addiction treatment, as part of a comprehensive treatment program.